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From vaccines to breakthrough therapies, responsible animal testing has been vital to developing safe, effective treatments and advancing modern medicine.
Before Human Trials Begin
Animal testing is the use of animals in biomedical research to understand how new drugs and treatments affect a living body. Scientists study how medicines are absorbed, processed, and eliminated — and whether they cause any harmful effects.
This essential research happens during the preclinical stage, before any human volunteers are involved. It helps ensure that only safe, effective therapies move forward to clinical testing.
Ensuring Safety Before Human Trials
Detects Toxicity Early
Determines Safe Dosage
Evaluates Organ Health
Protects Human Volunteers
Global Standards for Safety
Regulatory agencies in the United States and around the world require animal testing data before approving human clinical trials. This ensures that every new treatment meets strict safety and ethical standards before reaching patients.
Ethics and Oversight
Animal testing in the United States is governed by strict laws and oversight. Each study must justify its use of animals, minimize numbers, and ensure humane care at every stage.
The Animal Welfare Act
Public Health Service (PHS) Policy
Institutional Animal Care and Use Committees (IACUCs)
Voluntary AAALAC Accreditation
Innovating for the Future
Scientists are developing promising alternative methods — including computer modeling, cell-based systems, organoids, and advanced imaging. These approaches model specific biological processes but do not yet replace the whole-organism data required for comprehensive drug safety testing. Animal testing remains essential for understanding how medicines affect the whole body.
Predictive Digital Simulations
Uses advanced algorithms to model biological systems and forecast drug behavior before testing begins.
Studying Drugs at the Cellular Level
Tests how treatments interact with specific human or animal cells to assess effects on a smaller scale.
Miniature Models of Real Organs
Lab-grown organoids replicate human tissues, offering insight into disease and treatment responses.
Visualizing Science in Motion
Enables researchers to observe biological processes and treatment effects in real time.
The Impact of Responsible Research
Many of today’s life-saving treatments — from cancer therapies and heart medications to vaccines and rare disease cures — were made possible through responsible animal testing. Without these studies, modern medicine as we know it would not exist.
The 3Rs are the foundation of ethical animal research. They guide scientists to replace animals where possible, reduce the number used, and refine methods to minimize discomfort. This framework ensures research is conducted responsibly and only when scientifically necessary — maintaining the highest standards of animal welfare and patient safety.
Replacement
Use non-animal methods — like computer models or cell cultures — whenever possible.
Reduction
Minimize the number of animals used while ensuring reliable scientific results.
Refinement
Improve care and procedures to reduce pain, stress, and discomfort.
Since 1981, FBR has championed ethical animal research to drive innovation in medicine. Your support helps us continue educating the public and empowering the research community to improve lives across species.
